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Updated: Jun 25, 2025

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PHF2通过凝聚蛋白调节神经干细胞中的基因组拓和DNA复制

Jia Feng1, You Heng Chuah1,2, Yajing Liang1

  • 1Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117593, Singapore.

Nucleic acids research
|May 29, 2024
PubMed
概括

基因组脱甲基酶PHF2与凝聚素合作,调节神经干细胞中的DNA复制. 失去PHF2会激活休眠的起源,通过削弱拓相关域 (TADs) 来破坏复制.

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