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膀瘤中的微生物群诱导的炎症反应促进了上皮细胞-介质细胞过渡和增强的免疫透

Qiang Li¹, Yichao Sun², Kun Zhai¹

¹Department of Urology, Harbin Medical University Cancer Hospital, Harbin, People's Republic of China.

Physiological genomics

|May 29, 2024

概括

这种瘤是瘤.

科学领域:

在瘤学瘤学.
微生物组研究微生物组研究
免疫学免疫学免疫学

背景情况:

瘤免疫微环境 (TIME) 是由瘤内微生物群调节的.
连接肠道细菌与膀尿癌 (UCB) 中的TIME的特定机制尚未完全理解.

研究的目的:

调查内微生物群在影响UCB中的TIME中的作用.
阐明细菌影响UCB进展和免疫治疗反应的分子机制.

主要方法:

来自402名UCB患者 (TCGA) 的配对宿主转录组和瘤微生物组数据的分析.
微生物组概况与表皮细胞-介质细胞转换 (EMT) 相关的基因表达之间的相关性分析.
在接受免疫治疗的348名膀癌患者的独立队列中验证.

主要成果:

内微生物组概况与EMT相关的基因表达有显著的相关性.
特定的细菌属,Lachnoclostridium和Sutterella,与通过炎症促进EMT有关.
细菌诱导的炎症增强了免疫透,影响了患者的生存率和免疫治疗结果.

结论:

内微生物群,特别是Lachnoclostridium和Sutterella,可以促进EMT并影响UCB中的TIME.
这种机制会影响患者的预后和对免疫治疗的反应.
这些发现为UCB提供了潜在的向治疗策略.

关键词:

表皮细胞-介质细胞过渡.这是一种炎症炎症炎症炎症.肠道内口微生物群瘤免疫微环境是一个微环境.膀的尿路癌膀的尿路癌

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