新生儿天生的免疫反应在侵袭性候群病中
J A G Suárez1, R J N Calumby2, D P Silva2
1Universidade Federal de Ouro Preto - UFOP, Ouro Preto, MG, Brasil.
概括
新生儿新生儿的新生儿
科学领域:
- 免疫学 免疫学 免疫学
- 新生儿医学 新生儿医学
- 传染性疾病 传染性疾病
背景情况:
- 与医疗相关的感染,特别是Candida spp.,在重症新生儿中很常见.
- 新生儿与生俱来的免疫防御机制对侵袭性角膜病并未完全理解.
研究的目的:
- 划出了保护新生儿免受侵袭性 кандидоз病的先天免疫机制.
- 提高对新生儿免疫学在对抗真菌感染方面的理解.
主要方法:
- 综合性文献审查 (2002-2020年).
- 在Scopus,Scifinder,Medline,Web of Science,ScienceDirect和Scielo进行了搜索.
- 关键词:天生的免疫力,侵入性角膜炎,婴儿新生儿.
主要成果:
- 新生儿天生的免疫包括识别,信号和响应启动.
- 关键机制包括抗微生物,细胞,活性氧物种和模式识别受体 (PRR).
- 复杂的细胞信号通路对于防御至关重要.
结论:
- 本综述阐明了新生儿对侵入性Candida感染的先天免疫反应.
- 增强的知识可以为减少由传播性真菌感染引起的新生儿死亡率的策略提供信息.
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