长期COVID患者的亲炎性细胞因子 (Proinflammatory Cytokines) 个人资料在变体时代之间有所不同
Ravindra Ganesh1, Siddhant Yadav1, Ryan T Hurt1
1Mayo Clinic, Rochester, MN, USA.
Journal of primary care & community health
|May 29, 2024
概括
来自早期SARS-COV-2时代的长期COVID患者显示出更高的炎症性细胞因子水平. 症状在各个变种中保持一致,表明长期COVID.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 病毒学 病毒学
背景情况:
- 长期COVID影响超过30%的COVID-19患者,呈现持续症状超过30天.
- 增加的外周细胞因子,包括IL-6,IL-1β和TNF-α,与长期COVID有关.
- 已经出现了SARS-COV-2变种,可能会影响疾病的进展和结果.
研究的目的:
- 为了研究长期COVID患者的细胞因子概况.
- 为了分析不同SARS-COV-2变种时代的这些个人资料.
- 为了确定细胞因子签名是否与特定的变异或时代相关.
主要方法:
- 在390名长期COVID患者中分析了临床细胞因子面板.
- 患者被分为四个不同的时代:野生类型/α,α/β/gamma,delta和omicron.
- 细胞因子测试的时间和特定细胞因子水平在各个时代之间进行了比较.
主要成果:
- 与奥米克朗时代相比,瘤亡因子α和中白素-1β在早期变异时代 (野生型/α) 中显著增加.
- 对于早期的时代来说,细胞因子面板测试的时间更长.
- 核体抗体在所有时代都被始终检测到.
结论:
- 早期时期的长期COVID患者与后期时期相比,表现出持续升高的炎症性细胞因子水平.
- 长期的COVID症状集群在各个变体时代中看起来是一致的.
- 长期COVID的潜在病理可能独立于外围细胞因子标志,表明复杂的多因素病因.
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