发芽分支期间的体内表观遗传漂移:基于细胞系的模型
Yifan Chen1,2, Agata Burian3, Frank Johannes2
1Department of Mathematics, Technical University of Munich, Garching 85748, Germany.
Genetics
|May 29, 2024
概括
植物分支会造成细胞瓶,影响遗传和表观遗传变化传播方式. 我们的模型表明,这种"体力漂移"导致在射击上性髓系 (SAM) 内固有的DNA甲基化变异.
科学领域:
- 植物发育生物学植物发育生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 计算生物学是一种计算生物学.
背景情况:
- 植物架构是通过胚胎后器官生成而发展的,特别是侧向芽的形成.
- 脱离的 меристема模型解释了横向射击启动通过前体细胞从射击角 меристема (SAM).
- 重复的分支导致"体力漂移",影响突变传播和表观遗传变化.
研究的目的:
- 模拟体力漂移对SAM表观遗传变异的影响.
- 研究细胞系独立如何影响植物发育过程中的突变传播.
- 了解植物美里系统中固有的表观遗传异质性.
主要方法:
- 从SAM外围随机抽取前体细胞样本,正式制定了一个脱离的多元系统模型.
- 在重复分支过程中模拟体力漂移和表皮动力学.
- 分析了由此产生的细胞系和DNA甲基化模式.
主要成果:
- 随着时间的推移,体力漂移会在SAM中产生多样化的细胞系.
- 表观遗传变异受分支频率,漂移强度和表观突变速率的影响.
- 预测细胞对细胞DNA甲基化异质性的融合到非零状态.
结论:
- 表观遗传变异是由于发育过程而导致的SAM细胞群体的内在性质.
- 身体漂移是塑造植物表观遗传景观的关键因素.
- 这些发现为对多年生植物和克隆植物体内表观基因组多样性的研究提供了信息.
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