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综合生物信息学方法揭示与心血管疾病有关的枢纽基因和途径

Awatef Salah¹, Fériel Bouzid², Wala Dhouib²

¹Laboratory of Molecular and Cellular Screening Processes, Centre of Biotechnology of Sfax, University of Sfax, Sfax, Tunisia. awatefsalah25@gmail.com.

Cell biochemistry and biophysics

|May 29, 2024

概括

这项研究确定了与心血管疾病 (CVD) 相关的关键基因和途径. 炎症是一个核心特征,TNF和IL6等特定基因对心血管疾病的发展和进展至关重要.

科学领域:

基因组学就是基因组学.
生物信息学是一种生物信息学.
心血管研究研究心血管研究

背景情况:

心血管疾病 (CVD) 是全球主要的健康负担.
在心血管疾病发病的潜在分子机制和遗传因素尚未完全理解.

研究的目的:

使用综合生物信息学识别80种心血管疾病 (CVD) 病变的关键基因和信号通路.
在多种多样的心血管疾病中发现共同的遗传和通路特征.

主要方法:

微阵列和全基因组关联研究 (GWAS) 数据集的综合分析,以确定差异表达基因 (DEG).
基因本体学 (GO) 功能注释和蛋白质-蛋白质相互作用 (PPI) 网络分析以确定枢纽基因.
进行KEGG通路和GO丰富分析,以确定重要的信号通路.

主要成果:

鉴定了821个与80种心血管疾病相关的枢纽基因,其中包括135个常见基因. 像TNF,IL6,VEGFA和TGFB1这样的中心基因是普遍存在的,突出显示了炎症的作用.
糖尿病并发症中的AGE-RAGE信号通路是62种心血管疾病中关键的信号通路.
丰富分析揭示了与传染病和癌症的关联,作为心血管疾病的潜在常见风险因素.

结论:

综合生物信息学有效地确定了在心血管疾病发病过程中的关键枢纽基因和途径.
这些发现为开发针对心血管疾病预防,诊断和治疗的有针对性的干预措施提供了基础.
需要进一步的研究来阐明在心血管疾病中识别的枢纽基因的特定生物功能.

关键词:

心血管疾病是什么心血管疾病枢纽基因枢纽基因枢纽基因在状的中.炎症炎症是一种炎症.路径路径路径

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