相关实验视频
Updated: Jun 25, 2025

06:40
The Dyspepsia Educational Tool As a Novel Aid in Dyspepsia Management
Published on: June 29, 2019
6.6K
政府直接向消费者提供教育,以减少处方阿片类药物的使用:一个集群随机临床试验
Justin P Turner1,2,3, Alex S Halme4, Patricia Caetano5
1Centre for Medicine Use and Safety, Monash University, Parkville, Victoria, Australia.
JAMA network open
|May 29, 2024
概括
直接面向消费者的教育小册子没有增加处方阿片类药物的戒断,但确实导致更多的患者减少阿片类药物的剂量. 这项研究探讨了慢性非癌症疼痛患者长期使用阿片类药物的情况.
科学领域:
- 公共卫生 公共卫生
- 疼痛管理 疼痛管理
- 临床试验 临床试验
背景情况:
- 直向消费者教育已经减少了镇静剂的使用,但其对治疗慢性非癌症疼痛的处方阿片类药物的使用的影响尚不清楚.
- 长期使用阿片类药物,患有慢性非癌症疼痛的人群代表了教育干预可能有益的人群.
研究的目的:
- 评估来自政府实体的邮寄教育小册子是否可以减少长期阿片类药物消费者的处方阿片类药物使用.
- 为了比较这种教育干预措施的有效性与社区居民通常的护理.
主要方法:
- 一个集群随机临床试验,涉及4225名长期处方阿片类药物的成年人在加拿大马尼托巴省.
- 参与者被随机分配到接受教育宣传册 (干预) 或常规护理 (控制).
- 停用阿片类药物和减少剂量 (吗啡毫克相当量) 通过药房声明在6个月后被测量.
主要成果:
- 在6个月后,干预组 (11.0%) 和对照组 (11.0%) 之间没有发现阿片类药物戒断率的显著差异.
- 与对照组 (63.1%) 相比,干预组的参与者减少了阿片类药物剂量 (66.0%).
- 亚组分析显示,接受该小册子的男性,年轻成年人 (18-64岁) 和城市居民的剂量减少更大.
结论:
- 邮寄的教育小册子并没有显著增加长期使用慢性非癌症疼痛的处方阿片类药物的戒断.
- 这项干预与阿片类药物剂量减少的适度增加有关,特别是在特定的人口分组中.
- 进一步的研究可能会探索量身定制的教育策略,以优化减少阿片类药物使用.
相关概念视频
Prescription, Nonprescription and Orphan Drugs
721
Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
721
Drug Control Governance: Regulatory Bodies and Their Impact
156
Drug control governance involves the oversight and regulation of pharmaceuticals to ensure their safety and efficacy while preventing illegal drug use and trafficking. Regulatory bodies, including the US Food and Drug Administration (FDA) and the European Union's European Medicines Agency (EMA), play a central role in this process. These agencies evaluate the safety and efficacy of drugs before they can be marketed. They fund clinical trials and assess the benefits and risks associated with...
156
Opioid Analgesics: Morphine and Other Natural Cogeners
239
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
239
Drug Regulation
1.4K
Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...
1.4K
Drug Abuse and Addiction: Pharmacological Phenomena
465
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
465
Analgesia and Pain Management
582
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
582

