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研究放射治疗对循环瘤细胞PD-L1表达的影响:一项探索性研究

Rhandyka Rafli¹, Wirsma Arif Harahap², Soehartati Gondhowiardjo³

¹Faculty of Medicine, Universitas Andalas and Universitas Baiturrahmah, Padang, Indonesia.

Asian Pacific journal of cancer prevention : APJCP

|May 29, 2024

概括

新辅助放射治疗没有显著改变乳腺癌组织或循环瘤细胞 (CTC) 中的编程死亡配体1 (PD-L1) 表达. 然而,瘤组织中治疗前的PD-L1水平与治疗反应标准相关.

科学领域:

在瘤学瘤学.
免疫治疗是一种免疫疗法.
辐射疗法辐射疗法

背景情况:

循环瘤细胞 (CTC) 和编程死亡配体1 (PD-L1) 在癌症生物学和治疗反应中至关重要.
当地晚期乳腺癌患者经常接受新辅助放射治疗.

研究的目的:

研究新辅助放射治疗对瘤组织和CTC中PD-L1表达的影响.
探索PD-L1表达和治疗响应在不可手术的局部晚期乳腺癌之间的相关性.

主要方法:

一项前性队列研究,涉及27名患有不可手术的局部晚期乳腺癌的患者.
使用RT-PCR进行放射治疗前后的瘤组织和CTC中的PD-L1表达分析.
使用局部反应和RECIST标准评估瘤反应.

主要成果:

在放射治疗后的瘤组织或CTC中没有观察到PD-L1表达的显著变化 (p > 0.05).
在瘤组织中治疗前的PD-L1表达与RECIST标准显著相关 (p=0.021).
其他PD-L1表达和治疗反应之间的相关性在统计学上并不显著.

结论:

新辅助放射治疗可能不会显著影响瘤组织和CTC中的PD-L1表达.
在瘤组织中治疗前的PD-L1表达是治疗反应的潜在预测标志物 (RECIST).
需要进一步的研究,以充分理解PD-L1,CTC和放射治疗结果之间的复杂相互作用.

关键词:

循环瘤细胞 (CTCs) 是一种循环瘤细胞.新辅助性辐射疗法新辅助性辐射疗法在PD-L1中.在本地发达的乳腺癌.

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