性酸酶的患者衍生参考间隔,以支持对异酶和低酸酶的适当实用性
Jonathan Joseph1, Ibrahim A Hashim2,3
1University of Texas at Dallas, Richardson, TX, US.
Laboratory medicine
|May 29, 2024
概括
酸酸酶 (ALP) 的新参考间隔有助于识别低酸和减少不必要的测试. 这些特定于年龄和性别的范围提高了低水平和高水平ALP的诊断准确性.
科学领域:
- 临床生物化学 临床生物化学
- 儿科内分泌学 儿科内分泌学
- 诊断 实验室医学 诊断 实验室医学
背景情况:
- 准确的特定年龄和性别的性酸酶 (ALP) 参考间隔对于诊断低酸性和防止不必要的ALP异酶分析至关重要.
- 这项研究通过分析患者历史ALP数据来解决对精确参考范围的需求.
研究的目的:
- 从统计学上推导出性酸酶 (ALP) 的特定年龄和性别的参考间隔.
- 建立可靠的基准来识别潜在的低酸性和指导诊断决策.
主要方法:
- 在18个月内 (2021年7月至2023年3月) 收集的利用患者ALP值.
- 应用对数转换到ALP数据和代删除异常值.
- 使用修改的霍夫曼方法来确定参考间隔,生成累积频率图.
主要成果:
- 在各种儿科和成人年龄组中建立了全面的年龄和性别特定的ALP参考间隔.
- 详细的范围为新生儿 (<15天),婴儿 (15天-1年),儿童 (1-10岁),早期青少年 (10-13岁),中期青少年 (13-15岁),晚期青少年 (15-18岁) 和成年人 (>18岁) 提供.
结论:
- 实施这些衍生ALP范围可以将ALP异酶测试请求减少24.5%.
- 根据新的参考间隔,确定了9名新生儿,这些新生儿需要根据新的参考间隔进行潜在的低酸性查.
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