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关于研究纳米粒子和肺表面活性单层与粗粒度分子动力学方法之间的相互作用的综述

Kailiang Tang1, Xinguang Cui1

  • 1School of Aerospace Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.

Langmuir : the ACS journal of surfaces and colloids
|May 29, 2024
PubMed
概括

了解纳米粒子特性如何影响肺表面活性剂相互作用是开发更安全的肺药物递送系统的关键. 这种知识提高了纳米药物的有效性,并减少了副作用.

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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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