来自食物的上调剂和 ангиотензин转化酶的激活剂2:一篇评论
Zihan Wang1,2, Hongbing Fan3, Jianping Wu1,2
1Department of Agricultural, Food and Nutritional Science, 4-10 Ag/For Building, University of Alberta, Edmonton, Alberta T6G 2P5, Canada.
Journal of agricultural and food chemistry
|May 29, 2024
概括
ангиотензин转化酶2 (ACE2) 在心血管保护中起着至关重要的作用. 各种化合物,包括来自食物的分子,可以调节或激活ACE2,提供治疗潜力.
科学领域:
- 生物化学和分子生物学
- 心血管生理学心血管生理学
- 药理学 药理学是指药理学的学科.
背景情况:
- ангиотензин转化酶2 (ACE2) 是氨酸- ангиотензин系统 (RAS) 的组成部分,对心血管平衡至关重要.
- ACE2还作为氨基酸载体和病毒受体起作用,突出显示了其多方面的生物意义.
- ACE2 / Ang (1-7) / MasR级联对心血管保护至关重要.
研究的目的:
- 探索可以升级调节或激活ACE2的分子,因为它们具有显著的治疗潜力.
- 审查关于ACE2激活剂和上调剂的现有知识.
- 了解各种ACE2调节化合物的机制和有效剂量.
主要方法:
- 对ACE2激活剂和上调剂的研究的文献综述.
- 对不同类别的化合物报告的有效剂量和服用持续时间的分析.
- 检查了ACE2激活和上调的基础分子机制.
主要成果:
- 虽然已知很少有直接的ACE2激活剂,但许多化合物,包括来自食物的物质,充当ACE2上调剂.
- 在不同类型的化合物中,有效剂量有很大差异:生物活性 (10-50 mg/kg BW/day),蛋白质水解剂 (1000 mg/kg BW/day),植物化学品/维生素 (10-200 mg/kg BW/day) 和传统中医药 (1.25-12.96 g/kg BW/day).
- ACE2的激活涉及其曲区域,而上调则涉及各种信号通路,转录因子和表观遗传调节器.
结论:
- 调节ACE2活性的分子,特别是上调剂,具有相当大的治疗前景.
- 了解这些化合物的精确机制和最佳剂量是临床翻译的关键.
- 对新型ACE2调节器的进一步研究可能会导致新的疾病治疗和床边应用.
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