相关实验视频
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在细胞还原性手术和加热的腹腔内化疗中炎症性肠病
Almog Ben-Yaacov1, Nadav Elbaz1, Gal Schtrechman1
1Department of General Surgery, Sheba Medical Center, Tel Hashomer, Israel.
The American surgeon
|May 29, 2024
概括
在炎症性肠病 (IBD) 患者中,细胞还原性手术和加热的腹腔内化疗 (CRS/HIPEC) 显示了类似的短期结果,但趋向于较差的生存率. 对接受CRS/HIPEC治疗的IBD患者需要进一步的研究.
科学领域:
- 胃肠病学 胃肠病学
- 手术瘤学手术瘤学
- 在瘤学瘤学.
背景情况:
- 炎症性肠病 (IBD) 增加了胃肠癌的风险,往往预后更差.
- 细胞还原性手术和加热的腹内化疗 (CRS/HIPEC) 是对腹转移的治疗方法.
- 关于IBD患者的CRS/HIPEC结果的数据有限.
研究的目的:
- 为了比较与IBD和无IBD患者的CRS/HIPEC的短期和瘤结果.
- 评估CRS/HIPEC在IBD患者群体中的安全性和有效性.
主要方法:
- 一个前性维护的CRS/HIPEC数据库的回顾性审查.
- 在IBD和非IBD队列之间比较短期结果 (住院,并发症,重复手术) 和瘤结果 (复发,OS,DFS).
- 对232名患者的分析,包括10名IBD患者,他们接受了CRS/HIPEC治疗腺癌.
主要成果:
- 患有IBD的患者具有不同的人口特征 (较低的ASA,较低的高血压,较高的小肠初级),但类似的腹癌指数 (PCI) 和手术程度.
- 在IBD和非IBD组之间,短期结果包括并发症率 (60.3%整体,21.2%主要) 和重新手术率 (27%) 在IBD和非IBD组之间相似.
- 平均整体存活时间 (OS) 为IBD的19.6个月,而非IBD的53.2个月 (p=0.056). 在IBD患者中,无病生存时间 (DFS) 的中位数为4.9个月,而非IBD患者为9.4个月 (p=0.174).
结论:
- 在IBD患者中,CRS/HIPEC表现出与非IBD患者相似的并发症概况.
- 与非IBD队列相比,IBD队列中的瘤结局趋向于较差.
- 对于某些IBD患者来说,CRS/HIPEC可能是一个可行的选择,但结果需要仔细考虑.
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