HNF4alpha

Manasi Kotulkar1, Diego Paine-Cabrera1, Dakota R Robarts1

  • 1Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, United States.

概括

肝细胞核因子4alpha (HNF4α) 对于肝脏关键外传感器的功能至关重要,包括CAR,PXR和PPARα. 它的缺失会破坏这些传感器的激活,影响毒理反应.

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