在CAR T细胞治疗之前,通过老年医学评估指导的多学科诊所优化老年人
Samuel J Yates1, John F Cursio2, Andrew Artz3
1Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL.
Blood advances
|May 29, 2024
概括
一个以老年学评估为指导的多学科诊所 (GA-MDC) 有效地选择老年人进行仿真抗原受体T细胞 (CAR-T) 治疗. 建议继续治疗的患者的生存率改善,并发症减少,突出显示GA-MDC.
科学领域:
- 老年瘤学 老年瘤学
- 细胞疗法细胞疗法
- 血液学恶性瘤是什么
背景情况:
- 评估老年人 (≥65岁) 对仿真抗原受体T细胞 (CAR-T) 疗法提出了挑战.
- 老年评估 (GA) 可以确定老年患者的弱点.
- 多学科的方法可以优化CAR-T候选人评价.
研究的目的:
- 探索老年评估指导的多学科诊所 (GA-MDC) 在选择和优化老年人进行CAR-T治疗中的作用.
- 评估GA-MDC建议对患者结果的影响.
- 为了确定GA-MDC建议是否对整体存活率 (OS) 有预后.
主要方法:
- 在CAR-T治疗之前,61名老年人接受了GA-MDC的评估.
- 基于GA的结果,发布了一份无约束力的建议 ("继续"或"拒绝").
- 分析了患者的结果,包括整体存活率,停留时间和重症监护室 (ICU) 的入院.
主要成果:
- 53名患者中有47人最终在"继续"推后接受了CAR-T.
- 建议"继续"的患者住院时间较短,ICU入院率较低,相比于建议"下降"的患者.
- "继续"的建议与CD19和BCMA导向的CAR-T疗法的总生存率相比较高.
结论:
- GA-MDC有效地识别了适合CAR-T治疗的老年人.
- 在没有严重漏洞的情况下通过GA-MDC优化患者带来了有希望的结果.
- 在接受CAR-T的患者中,高脆弱性与毒性增加和生存率低下有关.
更多相关视频
09:34Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography
Published on: February 17, 2022
3.3K
09:12Author Spotlight: Advancements in Hypoxia-Sensitive CAR-T Therapy for Enhanced Cancer Immunotherapy
Published on: June 14, 2024
884
相关概念视频
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Tumor Immunotherapy
515
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
515
