之前的COVID-19感染和常见的整形外科手术后静脉血栓塞栓症之间的关联
Max L Silverstein1, Jennifer K Shah2, Priscila Cevallos3
1Division of Plastic & Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA.
概括
在常见的整形手术程序后,已解决的COVID-19感染并没有显著增加静脉血栓栓塞 (VTE) 的风险. 这项研究没有发现之前的SARS-CoV-2感染和术后的VTE在整形手术患者之间存在联系.
科学领域:
- 整形外科 整形外科 整形外科
- 血栓形成研究研究
- 传染病流行病学 传染病流行病学
背景情况:
- SARS-CoV-2 (COVID-19) 与高凝血性和静脉血栓塞栓症 (VTE) 风险有关.
- 关于COVID-19与不同外科专业的术后血栓形成的联系,存在相互矛盾的证据.
- 需要大规模的数据来澄清COVID-19和VTE在整形外科手术中的关联.
研究的目的:
- 为了调查之前的COVID-19感染和常见的整形手术后的VTE发生率之间的关联.
- 为了确定COVID-19是否是一个独立的风险因素,在整形手术患者的术后静脉瘤.
- 分析有或没有COVID-19病史的整形外科患者的VTE病率.
主要方法:
- 使用MerativeTM MarketScan®研究数据库 (2020-2021) 进行患者识别.
- 包括接受腹部泛尼古利切除术,乳腺缩小术或乳腺重建的女性患者.
- 员工倾向得分匹配和多变量后勤回归来分析COVID-19和VTE之间的关联.
主要成果:
- 总共有24,228名患者符合纳入标准;6%的人患有手术前的COVID-19诊断.
- 在1.3%的患者中发生了术后静脉动脉突发症.
- 倾向性得分匹配分析 (2754名患者) 显示COVID-19和手术后静脉瘤之间没有显著的相关性 (P=0.463).
- 与匹配的流行前队列相比,VTE发病率在大流行期间没有增加.
结论:
- 证据表明,在四种常见的整形手术程序的90天内,COVID-19感染和VTE之间没有明显的联系.
- 之前的SARS-CoV-2感染似乎不是这种患者群体中VTE的独立风险因素.
- 这些发现有助于理解选择性整形手术的背景下,与COVID-19相关的血栓风险.
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