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Updated: Jul 24, 2026

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猪养殖场的分子特征和潜在的宿主转换相关的Clostridioides difficile ST11

Jiewen Huang¹, Tinghua Li², Yongzhang Zhu³

¹Department of Laboratory Medicine, College of Health Science and Technology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Animal Health and Food Safety, School of Global Health, Chinese Center for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Veterinary microbiology

|May 29, 2024

概括

与猪相关的Clostridioides difficile ST11菌株表现出高抗生素耐药性和与人类菌株的遗传相似性,这表明潜在的传播. 监测这些不断变化的C. difficile菌株对于控制至关重要.

科学领域:

微生物学微生物学
基因组学就是基因组学.
兽医医学兽医医学兽医医学

背景情况:

困难菌 (C. difficile) 是一种机会性病原体.
菌株ST11在养猪场中普遍存在.
了解C. difficile的遗传多样性和传播是至关重要的.

研究的目的:

分析来自养猪场的C. difficile ST11菌株的分子流行率和遗传多态性.
为了将与猪相关的C. difficile菌株与公共数据库中的菌株进行比较.
调查动物和人类之间潜在的传播途径.

主要方法:

全基因组测序和对24种猪C. difficile ST11菌株的生物信息分析.
使用NCBI病原体数据库识别毒性和抗生素耐药性基因.
细胞毒性测定用于评估毒素A和B的功能.

主要成果:

猪C. difficile ST11菌株对β-乳糖酶,氨基糖化物和四环素具有普遍的耐药性.
一个独特的分离物 (菌株27) 显示tcdA删除和高抗生素耐药性.
动物和人类C. difficile菌株之间的遗传相似性表明潜在的传播.
大多数ST11菌株拥有可调动的等离子体.

结论:

与猪相关的C. difficile ST11菌株与数据库菌株相比,具有较少的毒性基因.
持续监测C. difficile的演变对于有效的控制策略至关重要.
了解宿主转换和遗传变化有助于预防C. difficile感染.

关键词:

克洛斯特里迪奥伊德斯困难菌细胞毒性试验细胞毒性试验分子表征的分子表征.NT1一个人的生活 ST11 ST11 在这里.

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