Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Nursing Clinical Information System01:27

Nursing Clinical Information System

767
Nursing Clinical Information System (NCIS)
A Nursing Clinical Information System (NCIS) is a specialized type of healthcare information system tailored to meet the unique needs of nursing practice. It incorporates the principles of nursing informatics to streamline information management and improve the quality of care delivery.
Critical attributes of NCIS include:
767
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Drug Discovery: Overview01:26

Drug Discovery: Overview

7.8K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
7.8K
Factors Influencing Drug Absorption: Disease States and Pharmacology01:25

Factors Influencing Drug Absorption: Disease States and Pharmacology

497
Multiple disease states can significantly influence the oral drug absorption process by affecting blood flow and the functionality of the gastrointestinal (GI) system. Various GI diseases, including conditions that alter GI motility, such as diarrhea, decreased acid secretions (achlorhydria), and infections, have been associated with reduced drug absorption.
Substances such as alcohol and specific drugs, including antineoplastics, can also negatively impact drug absorption. For instance,...
497
Health Information Technology and Healthcare Information System01:30

Health Information Technology and Healthcare Information System

827
Health Information Technology (HIT)
Health Information Technology, commonly called HIT, integrates advanced information systems and technology in healthcare settings. Its primary functions include:
827
Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

3.9K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
3.9K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

BioRENLI: enhancing large language models for biomedical relation extraction through preference-aligned natural language inference.

Health information science and systems·2026
Same author

Arginine-substituted Mastoparan-C derivatives combat dual bacterial pathogens: <i>in vitro</i> mechanistic insights and <i>in vivo</i> efficacy in polymicrobial wounds.

Microbiology spectrum·2026
Same author

Endoscope-assisted transoral removal of benign midline cervical neoplasms: A preliminary study.

Oral and maxillofacial surgery·2026
Same author

Epithelial cell-based multi-omics integration identifies SPINK5 and SRI as novel diagnostic biomarkers for ulcerative colitis.

Frontiers in pharmacology·2026
Same author

Dexmedetomidine for Reducing Mortality in Patients with Sepsis and Concomitant Heart Failure: A Retrospective Cohort Study.

Journal of intensive care medicine·2026
Same author

Self-powered TENG sensor based on hybrid energy: tilt angle and wind-speed research on dual parameter sensing and intelligent fault warning of transmission lines.

Nanoscale·2026

相关实验视频

Updated: Jun 25, 2025

A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports
07:35

A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports

Published on: October 13, 2023

1.6K

知识增强注意力聚合网络用于药物推.

Jiedong Wei1, Yijia Zhang1, Xingwang Li1

  • 1School of Information Science and Technology, Dalian Maritime University, Dalian, Liaoning, China.

Computational biology and chemistry
|May 29, 2024
PubMed
概括

这项研究介绍了KEAN,这是一个通过分析患者健康记录来准确推药物的深度学习模型. 凯恩改善了患者代表性,并减少了药物相互作用,以获得更好的健康结果.

关键词:
注意聚合网络的注意力聚合网络.药物药物相互作用图形的卷积可以表示.药物推 药物建议

更多相关视频

Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma
13:18

Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma

Published on: March 3, 2023

1.2K
A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

15.9K

相关实验视频

Last Updated: Jun 25, 2025

A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports
07:35

A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports

Published on: October 13, 2023

1.6K
Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma
13:18

Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma

Published on: March 3, 2023

1.2K
A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

15.9K

科学领域:

  • 医疗信息学 医疗信息学
  • 医疗保健中的人工智能
  • 临床决策支持 临床决策支持

背景情况:

  • 深度学习在医疗应用中显示出前景,特别是在药物推方面.
  • 患者的临床记录包含冗余的信息,可能会影响健康结果.
  • 现有的模型往往无法捕捉个别诊断和手术的影响,限制了患者的代表性和建议准确性.

研究的目的:

  • 提出KEAN,一种新的药物推模型.
  • 通过汇总诊断和程序来改善患者代表性.
  • 通过结合医学知识和减少药物相互作用,提高药物推准确性和患者安全.

主要方法:

  • 开发了KEAN,一个整合注意力聚合网络和增强图形卷积的模型.
  • 在患者访问期间汇总个别诊断和程序,以确定影响疾病的重要特征.
  • 纳入复杂药物组合知识和降低药物相互作用 (DDI).

主要成果:

  • 与现有的先进方法相比,KEAN在MIMIC-III数据集上表现出卓越的性能.
  • 该模型有效地捕捉了影响患者疾病的重要特征.
  • 整合医学知识和DDI提高了药物推的质量.

结论:

  • 通过提高患者代表性,KEAN提供了一种有效的药物推方法.
  • 该模型汇总临床信息和利用医学知识的能力对于准确性至关重要.
  • 这项工作突出了先进的深度学习技术在个性化医学中的潜力.