磁力共振成像在区分双相性多叶膜间皮瘤中占主导成分方面的预测潜力
Ritu R Gill1, William G Richards2, Hillary Heiling3
1Beth Israel Deaconess Medical Center, Boston, MA, United States.
European journal of radiology
|May 29, 2024
概括
从扩散权重的MRI中获得的明显扩散系数 (ADC) 值可以区分以表皮质为主导的和以肉类质为主导的双相性多叶膜间皮质瘤. 较高的ADC值表明上皮质组织学的可能性更高,有助于手术前瘤的特征.
科学领域:
- 放射学 放射学是一门学科.
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 由于其混合的组织学组成部分,双相性膜间皮瘤 (PM) 提出了诊断挑战.
- 精确的术前分化表皮质主导 (BE) 和瘤主导 (BS) 瘤对于治疗规划至关重要.
研究的目的:
- 评估从扩散权重 (DW) 磁共振成像 (MRI) 获得的表面扩散系数 (ADC) 值在预测双相PM的主要组织学亚型方面的有效性.
- 建立一个潜在的手术前成像生物标志物,以区分表皮和肉类组件.
主要方法:
- 获得扩散权重的MRI扫描,并为84名双相PM患者生成ADC地图.
- 主要成分 (BE或BS) 的组织学确认是在术后获得的.
- 统计分析比较了BE和BS瘤之间的ADC值,使用递归分区和ROC分析进行了值.
主要成果:
- 分析了84名双相PM患者:69名 (82%) 的BE和15名 (18%) 的BS瘤.
- 与BS瘤相比,在BE瘤中观察到明显更高的平均ADC值 (p=0.026).
- 0.94 x 10-3 mm2/s的ADC切线值有效地区分了BE和BS瘤,较高的值预测了BE组织学 (RR=1.47,p=0.027).
结论:
- 从DW-MRI获得的手术前的ADC值可以有效地区分表皮质主导和肉类主导的双相性多叶膜间皮质瘤.
- 0.94 x 10-3mm2/s的ADC值可以作为一个有价值的工具,用于手术前的亚型,可能指导手术和治疗策略.
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