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作为纳米载体的双重改性粉,用于高效封装和核桃衍生活性的受控释放

Xuehang Wang¹, Yuan Qi¹, Weiyu Hou¹

¹College of Food Science and Engineering, Jilin Agricultural University, Changchun, 130118, PR China.

|May 29, 2024

概括

新型纳米细胞增强了核桃 (WP) 的胃肠道吸收. 这项研究开发了一种改性粉聚合物 (SB-CST-DCA),用于改善WP的输送,显示出增强的抗氧化活性和十二指肠的安全吸收.

科学领域:

生物材料科学生物材料科学
药物输送系统药物输送系统
食品化学食品化学

背景情况:

胃肠道屏障对的吸收提出了挑战.
改造的纳米细胞为改善口服输送提供了潜力.
核桃 (WP) 具有有益的生物活性,但生物可用性有限.

研究的目的:

为了合成和表征一种新的双改性粉聚合物 (SB-CST-DCA).
开发WP载荷的纳米细胞 (SB-CST-DCA-WP) 进行增强的口服输送.
评估纳米细胞的物理化学性质,稳定性,释放行为,安全性和吸收性.

主要方法:

在玉米粉 (CST) 上通过乙化和化将硫乙 (SB) 和脱氧醇酸 (DCA) 接种.
用载纳米细胞 (SB-CST-DCA-WP) 的制备和表征.
评估封装效率,负载能力,稳定性,pH响应释放,抗氧化活性,体外安全性和体外吸收.

主要成果:

在SB-CST-DCA纳米粒中,表现出高封装效率 (76.90%) 和高负荷 (18.27%).
纳米细胞表现出良好的稳定性和pH响应释放,增强了WP的抗氧化活性.
该复合物是安全的,无毒的,与血液相容的,主要在十二指肠中被吸收 (41.16%).

结论:

新的SB-CST-DCA纳米细胞有效地封装并提供核桃 (WP).
这些纳米细胞提高WP的生物可用性,增强抗氧化活性,并确保安全的吸收.
这个平台有望通过口服输送和其它生物活性化合物.

关键词:

具有抗氧化活性的抗氧化剂.在体外模拟模拟.纳米微粒是什么意思结构性表征结构性表征核桃酸是一种核桃酸.

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