暴露于空气污染,加速生物衰老和增加甲状腺功能障碍风险:来自全国前性研究的证据
Ruyi Liang1, Lieyang Fan1, Xuefeng Lai1
1Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
长期暴露于空气污染会增加甲状腺功能障碍的风险,包括甲状腺功能过高和甲状腺功能低下. 生物衰老可能在这种关联中发挥作用,特别是在老年人中.
科学领域:
- 环境健康 环境健康
- 内分泌学 在内分泌学.
- 老年学是一门学科.
背景情况:
- 长期暴露于环境空气污染是严重的公共卫生问题.
- 空气污染和甲状腺功能障碍 (甲状腺功能过高,甲状腺功能下降) 之间的关系尚未得到充分证实.
- 生物衰老在这些关联中的潜在作用需要进一步研究.
研究的目的:
- 确定长期暴露于空气污染和甲状腺功能障碍之间的关联.
- 探索生物衰老在与空气污染相关的甲状腺功能障碍中的作用.
主要方法:
- 来自英国生物银行的432,340名参与者的前性队列研究.
- 评估暴露于颗粒物 (PM2.5,PM10,PM2.5-10),二氧化 (NO2) 和氧化 (NO) 的情况.
- 使用Klemera-Doubal和表型年龄算法对生物衰老的评估.
- 使用Cox比例危险回归,相互作用和调解分析的分析.
主要成果:
- 在空气污染物和甲状腺功能低下的风险增加之间发现了显著的关联.
- PM2.5,PM10和NO2与甲状腺功能障碍的风险增加有关.
- 较高的空气污染水平和较晚的生物年龄与甲状腺功能障碍的风险更大相关.
- 加快的生物衰老部分介导了1.9%-9.4%的与空气污染相关的甲状腺功能障碍.
结论:
- 长期暴露于空气污染可能会增加甲状腺功能障碍的风险.
- 在生物学上较老的个体中,这种风险似乎增加了.
- 生物衰老可能与将空气污染与甲状腺功能障碍联系起来的机制有关.
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