凝血促进了抗生素耐药性基因在二次废水中的传播
Fazhu Wu1, Chao Yuan1, Chujin Ruan2
1Department of Civil Engineering, Hefei University of Technology, Hefei, 230009, China.
Environmental pollution (Barking, Essex : 1987)
|May 29, 2024
概括
污水处理厂 (WWTP) 可以无意中传播抗生素耐药性. 凝血减少了抗生素耐药细菌 (ARB),但可能会增强治疗后抗生素耐药基因 (ARG) 的转移,需要进一步的缓解策略.
科学领域:
- 环境微生物学环境微生物学
- 水处理技术水处理技术.
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 污水处理厂 (WWTP) 是抗生素和抗生素耐药细菌/基因 (ARB/ARG) 的关键储存库.
- 凝固是一种常见的废水废水净化三级处理方法.
- 凝血对ARB/ARG的出现和传播的影响尚不清楚.
研究的目的:
- 在模型WWTP中研究凝血对ARB和ARG的流行和传播的影响.
- 阐明凝血影响ARB/ARG动态的机制.
主要方法:
- 一个模型的WWTP被用来研究四种代表性的ARB类型 (四环素,硫甲醇,克林达米辛,西普罗夫洛辛耐药性).
- 使用聚化 (PAC) 和铁化 (FeCl3) 进行了凝血.
- 在凝血后和储存期间分析了与细菌结合相关的ARB水平,ARG转移和基因表达.
主要成果:
- 使用PAC和FeCl3的凝血显著降低了ARB水平 (分别有95%和90%的去除).
- 然而,在储存4天后,ARB水平比初始水平升了6-138倍.
- 凝固剂,特别是PAC,通过增强细胞与细胞的接触促进了ARG转移,并通过影响基因表达提高了结合效率.
结论:
- 虽然凝固可以净化废水,但矛盾的是,它可能会增加ARG的传播.
- 凝血诱导的细菌聚合和改变的基因表达有助于增加ARG转移.
- 有效的ARB/ARG管理策略对于三级废水处理至关重要,以减轻耐药性的传播.
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