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Updated: Jun 25, 2025

Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

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在MDM2和MDMX上的二次p53结合点的结构调整

Pirada Serena Higbee1, Guy W Dayhoff2, Asokan Anbanandam1

  • 1The Department of Molecular Biosciences, University of South Florida, 4202 E. Fowler Ave, Tampa, FL 33620, USA.

Journal of molecular biology
|May 29, 2024
PubMed
概括

热力学研究揭示了p53如何与MDM2和MDMX结合. 改变p53螺旋性的突变增强了结合,为开发向的p53抑制剂提供了见解.

关键词:
符合性的.结合折叠和结合的折叠和结合热量的热量容量热量容量分子动力学模拟模拟核磁共振光谱学 核磁共振光谱学

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