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向衰老细胞,重塑瘤微环境,提高抗癌疗效

Birong Jiang¹, Wei Zhang², Xuguang Zhang³

¹School of Pharmacy, Institute of Aging Medicine, Binzhou Medical University, Yantai, Shandong 264003, China.

Seminars in cancer biology

|May 29, 2024

概括

细胞衰老,一种不可逆转的细胞生长停止状态,在癌症中起着双重作用. 一种新型疗法,老化药,选择性地消除老化的细胞,以提高癌症治疗的疗效.

科学领域:

癌症生物学和衰老研究.
细胞衰老和瘤微环境 (TME).

背景情况:

细胞衰老是压力诱导的细胞命运,与衰老和癌症有关.
衰老细胞表现出改变的形态,新陈代谢和分泌因子 (SASP).
衰老可以抑制早期瘤的发展,但矛盾的是,它可以促进已建立的癌症.

研究的目的:

定义TME中的衰老细胞及其前瘤性作用.
探索老年疗法,特别是老年化药物,用于癌症治疗.
评估共同向癌细胞和衰老细胞的潜力.

主要方法:

在TME中审查和定义衰老细胞表型.
对衰老细胞与瘤微环境相互作用的分析.
突出老化药物管道及其治疗潜力.

主要成果:

在TME中的衰老细胞重新塑造了利基,影响了免疫力,并推动了癌症的演变.
衰老细胞有助于建立瘤的治疗耐药性.
抗癌药物显示出恢复治疗反应和抗癌疗效的潜力.

结论:

准TME中老化的细胞为癌症治疗提供了一个有希望的策略.
高龄化药物可以阻碍瘤的进展,并增强现有的癌症治疗方法.
共同准癌症和衰老细胞可能会改善治疗效益并减少复发.

关键词:

与衰老相关的分泌表现型衰老细胞是一个衰老的细胞.年老的药物.鼻疗法 (Senotherapy) 是一种鼻疗法.瘤微环境是一个微环境.

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