相关实验视频

Updated: May 6, 2026

Doppler Optical Coherence Tomography of Retinal Circulation

Doppler Optical Coherence Tomography of Retinal Circulation

Published on: September 18, 2012

结构性和功能性玻璃眼检测之间的一致频率:3D OCT和当前临床试验的纵向研究

Dhruv Manik¹, Kitiya Ratanawongphaibul², Janice Kim³

¹From the Boston University Chobanian & Avedisian School of Medicine (D.M.), Boston, Massachusetts, USA; Department of Ophthalmology, Glaucoma Service, Massachusetts Eye and Ear (D.M., K.R., J.K., E.T., M.A.M., C.L.O., T.C.C.), Boston, Massachusetts, USA; Harvard Medical School (D.M., K.R., J.K., E.T., H.L., M.A.M., C.L.O., T.C.C.), Boston, Massachusetts, USA.

American journal of ophthalmology

|May 29, 2024

概括

在同一次访问期间,结构和功能测试很少检测到青光眼的进展. 大多数情况下,青光眼的进展仅通过一到两项测试来确定,这凸显了全面监测的必要性.

科学领域:

眼科医生眼科眼科
医疗成像医学成像
临床试验临床试验

背景情况:

玻璃眼是全球不可逆转的失明的主要原因.
早期发现青光眼的进展对于及时干预和维护视力至关重要.
目前对青光眼进展的诊断方法依赖于结构和功能测试的组合.

研究的目的:

为了比较结构性和功能性测试之间的青光瘤进展检测的一致性.
评估一种新的三维 (3D) 光学连贯性断层扫描 (OCT) 边缘测量在检测青光眼的进展中的实用性.
评估结构和功能测试在同一研究访问中确定进展的频率.

主要方法:

对124名开放角眼患者进行前性队列研究,每年至少进行4次视察.
评估的测试包括光盘摄影 (DP),汉弗雷视野测试 (HVF 24-2),2D OCT视网膜神经纤维层 (RNFL) 厚度和3D OCT神经视网膜边缘 (最小距离带 - MDB) 测量.
基于事件的分析被用来分类眼睛作为每次访问的每个测试的进展者或非进展者,协议定义为同一眼睛在同一访问期间的进展.

主要成果:

结构性测试 (DP,RNFL,MDB) 与功能性HVF测试同时检测出只在5.0%至16.0%的眼睛中的进展.
3D OCT MDB测量显示,与DP和HVF测试相比,HVF测试的结构功能一致性更好 (16.0%对5.0%,P=0.04).
与轻度或重度眼相比,中度眼的眼睛结构和功能测试之间的一致性相似或更好.

结论:

结构和功能测试的青光眼进展通常不确定在同一临床访问期间的变化.
青光眼的进展最常被检测到只有一个或两个测试,表明需要多方面的监测策略.
这些发现表明,目前的临床监测可能会错过并发性进展信号,这强调了整合各种测试方式的重要性.

更多相关视频

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

Published on: July 24, 2020

相关概念视频

Glaucoma: Overview

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

Open Angle Glaucoma: Treatment

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...

Angle Closure Glaucoma: Treatment

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...