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使用激光诱导分解光谱学对人类恶性黑色素瘤中的元素分布进行成像

Hana Kopřivová¹, Kateřina Kiss², Lukáš Krbal³

¹Central European Institute of Technology (CEITEC), Brno University of Technology, Purkyňova 123, 612 00, Brno, Czech Republic.

Analytica chimica acta

|May 29, 2024

概括

激光诱导分解光谱学 (LIBS) 通过检测皮肤组织的基本变化来诊断恶性黑色素瘤的潜力. 这种技术在癌症和健康组织之间发现和水平的差异,有助于瘤诊断.

科学领域:

在瘤学瘤学.
生物物理学的生物物理.
分析化学分析化学

背景情况:

恶性黑色素瘤 (MM) 的诊断严重依赖于组织学.
在健康和瘤组织之间元素组成的差异被记录下来.
针对MM的新型诊断工具正在不断开发.

研究的目的:

评估激光诱导分解光谱 (LIBS) 作为恶性黑色素瘤的诊断工具.
为了研究MM检测元素组成的定量变化.
探索LIBS在区分MM亚型方面的潜力.

主要方法:

在17个恶性黑色素瘤样本和1个健康皮肤样本上使用激光诱导分解光谱 (LIBS).
分析了元素组成,重点关注和的分布.
使用LIBS成像来对元素进行详细的空间分析.

主要成果:

LIBS在恶性黑色素瘤和健康的皮肤组织之间显示出明显的元素分布模式.
在癌症组织中观察到和度的显著差异.
初步迹象表明,在不同的MM亚型中,元素度会有所不同.

结论:

作为恶性黑色素瘤的定量诊断工具,LIBS显示出前景.
通过LIBS的元素分析可以区分瘤和健康组织.
需要进一步研究更大的样本大小,以确认LIBS在MM亚型分类和理解瘤生物学中的实用性.

关键词:

化学分析化学分析皮肤癌是一种皮肤癌.诊断诊断诊断诊断数字组织病理学数字组织病理学光学发射光谱学光学发射光谱学皮肤瘤是一个皮肤瘤.

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