在治疗甲状腺疾病的放射性治疗后,唾液腺体的组织病理变化
Xiao Li1, Jia-Zeng Su1, Yan Gao2
1Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing, China.
概括
甲状腺疾病的放射性 (RAI) 治疗会导致唾液腺损伤,包括导管细胞变化和组织缩. 这些组织病理学变化在治疗后的症状和无症状患者中都被观察到.
科学领域:
- 组织病理学 组织病理学
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
背景情况:
- 放射性 (RAI) 治疗是甲状腺疾病的常见治疗方法.
- 在唾液腺上RAI治疗的潜在副作用需要彻底调查.
- 了解这些影响对于管理患者健康和治疗结果至关重要.
研究的目的:
- 为了评估人类唾液腺在放射性 (RAI) 治疗甲状腺疾病后的组织病理变化.
主要方法:
- 对16名患者的回顾性分析,这些患者在RAI治疗甲状腺疾病后接受了唾液腺手术.
- 对临床记录和唾液腺样本的组织病理幻灯片的审查.
- 组织病理学发现与患者症状学的相关性.
主要成果:
- 有症状的患者表现出管道细胞细胞质真空化,管道细胞层失调,管道狭窄/扩张和剥落的上皮细胞.
- 在有症状的病例中,腺膜膜异位变化包括严重的状缩,脂肪含量增加和围导纤维化.
- 无症状患者还显示了管道细胞真空化,状缩,脂肪含量增加和周周纤维化.
结论:
- 在RAI治疗后唾液腺的关键本病学变化包括导管细胞真空化,状缩,脂肪增强和围导纤维化.
- 这些唾液腺改变在RAI治疗后的症状和无症状个体中都存在.
- 这些发现突出了RAI治疗对唾液腺组织结构的重大影响.
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