揭示前额叶皮层-底侧杏仁体通路在精神分裂症认知障碍中的作用:在患者和小鼠模型中的多模式研究

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Jiaquan Liang^1,2, Lei Chen¹, Yongbiao Li¹

¹Key Laboratory of Ethnomedicine of Ministry of Education, Center on Translational Neuroscience, College of Life and Environmental Sciences, Minzu University of China, Beijing, China.

Schizophrenia bulletin

|May 29, 2024

概括

激活中间前额叶皮层 (mPFC) - 底侧杏仁体 (BLA) 途径改善了精神分裂症 (SCZ) 鼠标模型中的认知缺陷. 血液外体mRNA可以作为SCZ诊断的非侵入性生物标志物.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
基因组学就是基因组学.

背景情况:

精神分裂症 (SCZ) 与显著的认知障碍有关.
中间前额皮层 (mPFC) - 底侧杏仁体 (BLA) 途径在SCZ相关的认知缺陷中的作用仍然不清楚.

研究的目的:

调查mPFC-BLA途径在与精神分裂症相关的认知障碍中的参与.
探索SCZ诊断的潜在的非侵入性生物标志物.

主要方法:

使用临床尺度,磁共振成像 (MRI),单细胞RNA测序和光遗传学.
使用甲基酸甲醇诱导的SCZ小鼠模型来研究认知缺陷.
使用病毒载体输送和立体毒性注射研究了mPFC-BLA神经连接.

主要成果:

与对照人群相比,SCZ患者在脊侧前额皮层 (DLPFC) 和BLA中显示出大脑体积和神经活动的差异.
减少DLPFC和BLA体积与较低的认知功能得分相关.
激活mPFC-BLA通路可以改善SCZ模型小鼠的认知缺陷.
单细胞转录组学揭示了SCZ模型小鼠的BLA中的差异性基因表达,SCZ患者的血液外基因体中发现了类似的基因表达.

结论:

该mPFC-BLA通路在SCZ相关的认知障碍中起着至关重要的作用.
准mPFC-BLA通路为SCZ提供了潜在的治疗策略.
血液外体mRNA显示为SCZ诊断的非侵入性生物标志物具有前途.

关键词:

基本侧面的杏仁体在外基因组中,外基因组是外基因组.磁共振成像技术的使用中部前额叶皮层中部前额叶皮层视觉遗传学视觉遗传学精神分裂症是一种精神分裂症.

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