乳腺癌遗传检测中的种族差异可以通过咨询来缓解
Julie B Siegel1, Melanie Bertolino2, Rupak Mukherjee2
1Department of Surgery, Medical University of South Carolina, Charleston, SC, USA. siegelju@musc.edu.
Annals of surgical oncology
|May 29, 2024
概括
遗传咨询出席率的种族差异仍然存在,但一旦患者接受咨询和遗传检测,就会消失. 教育是改善获得和利用遗传服务的关键.
科学领域:
- 医学遗传学 医学遗传学
- 健康差异 在健康上的差异
- 在瘤学瘤学.
背景情况:
- 种族差异在基因测试访问是一个众所周知的问题.
- 最近的进展旨在提高基因测试的可访问性.
- 这项研究调查了遗传咨询和测试中持续存在的种族差异.
研究的目的:
- 确定在遗传咨询出席和遗传检测完成方面是否存在种族差异.
- 确定不同种族群体中遗传服务利用不足的因素.
主要方法:
- 对596名乳腺患者进行了回顾性审查,这些患者被转介到遗传咨询 (2017-2019).
- 使用了单变量和多变量逻辑回归分析.
- 评估了与遗传咨询出席和测试完成相关的因素.
主要成果:
- 与白人患者相比,黑人患者参加遗传咨询的可能性明显低.
- 缺乏家族病史和没有当前的癌症诊断也预测出院率较低.
- 一旦咨询完成,基因测试率在种族群体之间是相似的,没有测试收件的显著预测因素.
结论:
- 种族和参加遗传咨询之间存在显著的联系.
- 在基因测试中的种族差异在咨询后消失,这凸显了教育的重要性.
- 增加对遗传测试目的和重要性的教育,可以提高利用率.
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