在乳腺癌手术后持续的术后疼痛中的肠道微生物群
Khaled Masaud1, James M Collins2,3, Raul Cabrera Rubio2,4,5
1Department of Anaesthesia and Intensive Care Medicine, Cork University Hospital and University College Cork, Cork, Ireland.
Scientific reports
|May 29, 2024
概括
持续的手术后疼痛 (PPSP) 与肠道细菌多样性有关. 较低的多样性与严重的疼痛相关,而像Bifidobacterium longum这样的特定细菌与乳腺癌手术后的疼痛缓解有关.
科学领域:
- 微生物学 微生物学
- 疼痛研究 疼痛研究
- 在瘤学瘤学.
背景情况:
- 术后持续性疼痛 (PPSP) 是一种常见的,未被认可的临床问题,影响全球数百万人.
- 目前的预防策略包括微创手术和术后止痛.
- 新兴研究强调了肠道微生物群在疼痛调节中的作用.
研究的目的:
- 在乳腺癌患者中研究肠道微生物组成和PPSP之间的关系.
- 探索肠道细菌,手术后的疼痛和焦虑之间的潜在联系.
主要方法:
- 一项前性观察性研究,涉及68名女性成年乳腺癌患者.
- 从45名患者的便样本中分析肠道微生物群组成.
- 在手术后的不同时间点评估疼痛和状态特征焦虑.
主要成果:
- 在患有严重PPSP的患者中,经手术60分钟和12周后观察到肠道微生物群的α多样性明显较低.
- 包括Bifidobacterium longum和Faecalibacterium prausnitzii在内的特定细菌群与12周没有疼痛有关.
- 不同的细菌种群,包括Megamonas hypermegale和Roseburia hominis,与PPSP的存在有关.
结论:
- 这项研究提供了第一个证据,表明肠道微生物群组成与PPSP存在或不存在之间的特定关联.
- 研究结果表明,肠道微生物群可能在PPSP发育中发挥作用.
- 这些见解可以为未来针对肠道微生物群的治疗策略提供信息,以预防和管理PPSP.
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