一项随机对照的临床试验表明,在接受老年和NAD+前体结合剂的老年狗中,老主评估的认知功能得到了改善
Katherine E Simon1, Katharine Russell1,2, Alejandra Mondino1
1Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.
Scientific reports
|May 29, 2024
概括
一种新型化合物LY-D6 / 2在三个月内改善了狗的业主评估的认知功能. 这种NAD+前体和老化剂也可能微妙地增强狗的脆弱性,活动和幸福感.
科学领域:
- 老年学是指老年学的学科.
- 兽医医学 兽医医学 兽医医学
- 生物化学 生化学
背景情况:
- 细胞衰老和NAD+耗尽有助于与年龄相关的认知和运动能力下降,在狗和人类.
- 狗的认知功能障碍 (CCD) 反映了人类的认知衰老,使得狗成为研究干预措施的宝贵模型.
研究的目的:
- 评估LY-D6 / 2的疗效,一种新的NAD +前体和老化剂的组合,用于改善轻度至中度认知障碍的狗的认知功能和活动.
- 评估LY-D6/2在犬群中的安全性和耐受性.
主要方法:
- 一个随机的,安慰剂控制的试验,涉及70只被诊断为轻度至中度认知障碍的狗.
- 狗被分配到安慰剂,低剂量或全剂量LY-D6/2组.
- 主要结局包括认知障碍 (犬类认知功能障碍评分表) 和体力活动 (通过活动追踪器监测) 在3个月和6个月的变化.
主要成果:
- 从基线到3个月终点 (p=0.02) 观察到所有者评估认知功能的显著改善 (CCDR得分),在治疗组中从基线到3个月终点 (p=0.02),全剂量组的下降最为显著.
- 使用内部认知测试或群体之间的测量体育活动水平,没有发现认知功能的显著差异.
- 虽然在统计学上并不显著,但在全剂量组中,更高比例的狗在脆弱性,活动性和幸福度方面表现出了业主报告的改善.
结论:
- 在3个月的时间内,LY-D6/2在改善狗的业主评估的认知功能方面表现出有效性.
- 复合物可能会提供更广泛的,尽管更微妙的,与脆弱性,活动和所有者感知的整体幸福感相关的好处.
- 在所有组中,不良事件均分布,这表明了有利的安全性.
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