社会隔离行为的多基因风险及其对精神病理学和人格的影响
Adam J Socrates1, Niamh Mullins2,3,4, Ruben C Gur5
1Department of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Pl., New York, NY, 10029, USA. adam.socrates@mssm.edu.
Molecular psychiatry
|May 29, 2024
概括
遗传因素影响社会隔离行为 (SIB),发现了一小部分遗传成分. 这些遗传倾向与友,精神疾病和孤独相关,但因果关系仍然未被证明.
科学领域:
- 行为遗传学 行为遗传学
- 精神病学遗传学 精神病学遗传学
背景情况:
- 社会孤立与精神问题有关,但其潜在的行为驱动因素尚不清楚.
- 了解社会隔离行为 (SIB) 的遗传基础对于精神病学研究至关重要.
研究的目的:
- 使用全基因组关联研究 (GWAS) 识别与社会隔离行为 (SIB) 相关的遗传变异.
- 研究SIB与社会特征,精神疾病和认知因素之间的遗传相关性.
- 探索SIB遗传倾向的发育表现.
主要方法:
- 在449,609名英国生物库参与者中进行全基因组关联研究 (GWAS),以确定SIB位点.
- 在一个独立的队列中 (ALSPAC) 导出SIB的多基因风险得分 (PRS),以评估12岁和18岁的友得分的关联.
- 链接不平衡 (LD) 得分相关性和门德尔随机化 (MR) 来检查与相关特征的遗传相关性和因果关系.
- 基因组结构方程建模 (SEM) 以阐明共享的遗传因素.
主要成果:
- 与SIB相关的17个位点被确定为全基因组显著性,解释了SNP遗传率的4%.
- 18岁时SIB PRS与友得分有显著的关联,表明对社会特征的遗传预测.
- 在SIB和自闭症谱系障碍 (ASD),精神分裂症,严重抑郁症 (MDD),教育成就,外向和孤独之间发现了基因相关性.
- 通过MR检测SIB与其他特征之间没有发现因果关系.
- SEM揭示了SIB,神经病,孤独,MDD和ASD的共同遗传因素.
结论:
- 社会隔离行为 (SIB) 有一个小的,遗传的组成部分.
- 对SIB的遗传因素与友,精神疾病和孤独有关.
- 虽然SIB与基因相关,但似乎与研究的特征没有直接的因果关系.
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