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在接受治疗的自身免疫甲状腺炎患者中,自主功能受损和体感障碍
Bojana Bazika-Gerasch1,2,3,4,5, Nina Kumowski6, Elena Enax-Krumova7
1Diabetes, Endocrinology and Metabolism Section, Department of Internal Medicine I, St. Josef Hospital, Ruhr University Bochum, Gudrunstr. 56, 44791, Bochum, NRW, Germany.
Scientific reports
|May 29, 2024
概括
甲状腺功能低下症和自身免疫性甲状腺炎 (AIT) 即使在治疗中也会降低生活质量 (QoL). 神经病变症状,包括自主和体感官功能障碍,有助于这种"T综合征".
科学领域:
- 神经学 神经学
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
背景情况:
- 甲状腺功能低下症和自身免疫性甲状腺炎 (AIT) 尽管接受了levothyroxine治疗,但会影响生活质量 (QoL),这种现象被称为"T综合征".
- 周围神经病变是未经治疗的甲状腺疾病的已知并发症,可能导致"T综合征".
研究的目的:
- 在接受治疗的甲状腺功能低下症和AIT患者中调查自主和体感神经功能.
- 探索神经功能,甲状腺自身免疫和生活质量之间的关系.
主要方法:
- 心率变化 (HRV) 分析和定量感官测试 (QST) 在29名AIT患者和治疗过的甲状腺功能低下症和27名健康对照进行.
- QST评估了小和大神经纤维功能和疼痛值.
- 还评估了自主心血管功能,甲状腺生物标志物,焦虑,抑郁和QOL.
主要成果:
- 36%的患者表现出体感神经纤维功能障碍,57%的患者表现出轻微的过敏症.
- 自主功能标志物和感官检测值与甲状腺抗体标位相关联.
- 焦虑,抑郁和QOL得分与抗体标位和HRV测量有关.
结论:
- 在接受治疗的甲状腺功能低下症和AIT患者的亚组中存在自主和体感功能障碍,导致 QoL 损伤.
- 神经病变症状和轻度过敏症可能是"T综合征"症状管理的目标.
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