血清25-基维生素D3水平与老年慢性病患者的认知障碍之间的关联
Jialing Zhang1, Aihua Zhang2,3
1Department of Nephrology, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Xicheng District, Beijing, China.
Scientific reports
|May 29, 2024
概括
低维生素D水平与老年慢性病患者的认知能力下降有关. 早期的维生素D查和干预可以帮助预防这些人的认知障碍.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内分泌学 在内分泌学.
- 老年病的医生 老年病的医生
背景情况:
- 低维他命症D在慢性病 (CKD) 患者中很普遍.
- 在老年CKD人群中,认知障碍是一个重大问题.
- 白蛋白尿是损伤和进展的标志物.
研究的目的:
- 为了研究维生素D缺乏和认知障碍在老年CKD患者与不同程度的白色素尿之间的联系.
- 为了确定维生素D水平是否与这个特定的患者群体的认知功能相关.
- 探索潜在的治疗策略,以预防CKD的认知衰退.
主要方法:
- 基于人口的横截面研究使用美国国家健康和营养检查调查 (NHANES) 数据 (2011-2014).
- 纳入标准:老年人 (≥60岁) 慢性病患者,尿中的白蛋白与肌素比率 (UACR) ≥30 mg/g.
- 使用CERAD单词列表学习评估认知功能;通过斯皮尔曼相关性和逻辑回归与倾向得分匹配 (PSM) 分析关联.
主要成果:
- 在25-基维生素D3 (25(OH) D3) 水平和认知评分之间发现了积极的关联.
- PSM分析表明,较高的25(OH) D3水平与更好的认知功能相关,特别是在CKD患者中,30 mg/g ≤UACR<300 mg/g (microalbuminuria).
- 较低的25(OH) D3水平与较差的认知表现有显著的关联,特别是在患有微专尿症的患者中.
结论:
- 低维他命D与老年CKD患者的认知障碍相关,这些患者患有白色素尿.
- 较高的维生素D水平可能会在这个人群中防止认知能力下降.
- 早期发现和干预维生素D缺乏症可能是管理渐进性病中认知功能的一个有价值的策略.
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