在右侧与左侧结肠癌的预后因素和生存差异
Mohammad Asghari-Jafarabadi1,2,3, Simon Wilkins4,5, John Paul Plazzer6
1Cabrini Research, Cabrini Hospital, Malvern, VIC, 3144, Australia.
Scientific reports
|May 29, 2024
概括
右侧结肠癌 (RCC) 的死亡率高,生存率低于左侧结肠癌 (LCC). 年龄,BMI和癌症阶段等因素对两种类型的患者的存活率都有重大影响.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 生物统计学 生物统计学
背景情况:
- 右侧结肠癌 (RCC) 和左侧结肠癌 (LCC) 由于胚胎学,流行病学和病理学差异而表现出明显的特征.
- 这些变异影响治疗方法和患者的结果,需要对生存决定因素有更深入的了解.
研究的目的:
- 用贝叶斯模型确定影响右侧结肠癌 (RCC) 与左侧结肠癌 (LCC) 患者生存的重要因素.
- 为了比较RCC和LCC患者的整体存活率 (OS) 和无复发存活率 (RFS).
主要方法:
- 从2010年1月到2021年12月的结直肠瘤数据库的回顾性分析.
- 包括2475名接受结肠癌手术的患者,包括人口统计数据,术后风险,治疗,死亡率和生存率.
- 应用贝叶斯模型来识别与OS和RFS相关的因素.
主要成果:
- 与LCC患者相比,RCC患者的死亡率更高,生存率略低 (P < 0.05).
- 与LCC相比,I-IV阶段的RCC始终表现出较差的OS和RFS (P<0.05).
- 显著的生存因素包括年龄,BMI,ASA得分,癌症阶段,并发症,瘤分化,淋巴结产量,器官切除,化疗和手术方法 (选择性与紧急).
结论:
- 在RCC和LCC之间存在关键差异,RCC通常与较差的生存结果有关.
- 患者特定的因素,如年龄,BMI,ASA得分,癌症阶段和并发症是结肠癌存活率的关键决定因素.
- 研究结果支持开发针对个体患者和瘤特征量身定制的个性化治疗策略,以改善结肠癌管理.
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