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Updated: Jun 25, 2025

A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9
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一种新型的小分子PCSK9抑制剂E28362可以改善高脂血症和动脉样硬化

Wei-Zhi Wang1, Chao Liu2, Jin-Que Luo1,3

  • 1State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, NHC Key Laboratory of Biotechnology for Microbial Drugs, National Center for New Microbial Drug Screening, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Beijing, 100050, China.

Acta pharmacologica Sinica
|May 29, 2024
PubMed
概括

一个新的小分子,E28362,通过阻止其与LDLR (低密度脂蛋白受体) 的相互作用来抑制PCSK9 (proprotein convertase subtilisin/kexin type 9). 这导致LDLR水平升高,LDL-C降低,以及动物模型中的超脂血症和动脉样硬化改善.

关键词:
E28362 是一个 E28362 的类型.这就是LDLR的LDLR.这是一种PCSK9抑制剂.动脉样硬化 动脉样硬化过高脂血症是什么意思

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