新型MAXPOWER生物抗菌液,用于根除口腔Helicobacter pylori
Yongkang Lai1,2, Xiaoyang Dong1, Yingxiao Song1
1Department of Gastroenterology, Changhai Hospital, Naval Medical University, 168 Changhai Road, Yangp u District, Shanghai, 200433, China.
BMC infectious diseases
|May 29, 2024
概括
MAXPOWER生物抗菌液有效地消灭口服的Helicobacter pylori (H. pylori),在临床试验中成功率高. 这种新型生物控制解决方案显示出出色的安全性和对肠道微生物群的最小影响,提供了一个有前途的治疗选择.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 口腔Helicobacter pylori (H. pylori) 感染是传播途径,并影响胃内根除成功.
- MAXPOWER生物细菌静止液是一种具有独特抗菌机制的新型复合生物制剂.
- 之前的研究证实了MAXPOWER强大的抗菌能力.
研究的目的:
- 为了评估MAXPOWER生物控制溶液对H.pylori的疗效.
- 确定MAXPOWER在临床患者口服H. pylori根除中的成功率.
- 评估MAXPOWER对肠道微生物群的安全性和影响.
主要方法:
- 在体外:活死细胞染色,血液溶解试验,板张,扫描电子显微镜.
- 转录学分析H. pylori基因表达在治疗后的变化.
- 在体内:为动物安全而进行H&E染色和16SrDNA测序.
- 临床试验:随机对照试验,使用安慰剂和MAXPOWER进行七天的 gargle.
主要成果:
- 在实验室中,MAXPOWER证明了出色的生物相容性和血液相容性.
- 在体外观察到口服H. pylori的有效根除.
- 在体内测试证实了良好的生物安全性,对肠道微生物群的影响最小.
- 转录学揭示了细胞膜破坏和代谢干扰作为抗菌机制.
- 临床试验显示口服H. pylori根除率为71.4% (ITT) 和78.9% (PP).
结论:
- MAXPOWER生物抗菌液对于口服H. pylori根除是安全有效的.
- 这项研究支持MAXPOWER作为口腔H. pylori感染的可行治疗剂.
- 根据证明的疗效和安全性,MAXPOWER的进一步临床应用是合理的.
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