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淋巴结转移在头部和部皮肤状细胞癌中的淋巴结转移
Qigen Fang1, Junhui Yuan2, Xu Zhang3
1Department of Head Neck and Thyroid, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, 450008, China. qigenfang@126.com.
BMC cancer
|May 29, 2024
概括
侧侧淋巴结会影响头癌的预后. 使用转移性淋巴结和外节延伸的新方法为皮肤状细胞癌提供了更好的生存预测.
科学领域:
- 在瘤学瘤学.
- 头部和部手术 头部和部手术
- 癌症预后 癌症预后
背景情况:
- 头部和部皮肤状细胞癌 (HNcSCC) 带来了重大治疗挑战.
- 在HNcSCC中侧侧淋巴结 (LNs) 的预后作用需要进一步澄清.
- 精确评估淋巴结参与对于改善局部区域控制 (LRC) 和整体存活率 (OS) 至关重要.
研究的目的:
- 评估状淋巴结对HNcSCC患者预后的影响.
- 开发和验证一种替代的淋巴结评估方法,以提高LRC和OS分层.
- 为了比较不同的分期系统在预测HNcSCC.结果的有效性.
主要方法:
- 对126名经过手术治疗的HNcSCC.患者的回顾性分析.
- 利用考克斯模型来分析状腺LN和各种LN评估方法对LRC和OS的影响.
- 使用C指数,Akaike信息标准和贝叶斯信息标准进行预测模型比较.
主要成果:
- 无论是内和周的LN状态都与患者的预后有显著的相关性.
- 宫LN中的外节延伸 (ENE),而不是状LN,预测LRC和OS降低.
- 拟议的LN评估方法在生存分层方面表现优于现有系统.
结论:
- 侧侧淋巴结是转移性HNcSCC的显著预后指标.
- 一种新的LN评估方法,考虑到转移性LN数量和宫ENE,显示了与当前AJCC N和O'Brien分期系统相比较的生存分层.
- 这种新方法有助于完善HNcSCC的预后和指导治疗策略.
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