[肠道毒性与Euphorbia ebracteolata毒性部分在Terminalia chebula加工前后的成分变化之间的相关性]
Wei-Hao Lin1, Hong-Li Yu2, Hao Wu2
1Pharmacology College, Nanjing University of Chinese Medicine Nanjing 210023, China.
概括
用Terminalia chebula加工Euphorbia ebracteolata可以显著降低其肠道毒性. 这归因于添加的素和酸,而不是二基结构的变化,使加工方法具有科学有效性.
科学领域:
- 药理学和毒理学 药理学和毒理学
- 自然产品化学 自然产品化学
- 传统中国医药 传统中国医药
背景情况:
- 欧福 (Euphorbia ebracteolata) 在传统医学中使用,但其潜在的肠道毒性需要研究.
- 处理方法可以改变药用草药的化学成分和安全性.
研究的目的:
- 调查Terminalia chebula (TCS) 处理对Euphorbia ebracteolata肠道毒性的影响.
- 用化学方法分析TCS处理前后E. ebracteolata的组成变化.
主要方法:
- 使用便中的水含量,炎症标志物 (TNF-α,IL-1β) 和小鼠模型中的组织损伤来比较肠道毒性.
- 使用高性能液体染色学-飞行时间质谱法 (HPLC-TOF-MS) 分析二甲,和酸.
- 使用HPLC量化四种特定的二氧化物 (HAO,JNB,FA,JNE).
主要成果:
- 原始E. ebracteolata提取物显著增加了肠道毒性标志物,并导致组织损伤.
- 经TCS处理的E. ebracteolata提取物显示减轻了肠道损伤和减少了炎症反应.
- 在HPLC-TOF-MS检测中,丁酸含量没有显著变化,但在加工后添加了素和酸. 惠普LC证实了二类的减少,损失归因于加工残留物.
结论:
- 通过TCS处理,可以有效地降低E. ebracteolata的肠道毒性.
- 毒性降低主要是由于加工过程中添加的素和酸的对抗作用,而不是由于二基结构的改变.
- 对E. ebracteolata的TCS处理的科学有效性得到了这些发现的支持.
关键词:
尤福里亚 (Euphorbia ebracteolata) 是一种的植物.切布拉 (Terminalia chebula) 是一个加工的加工厂.组成的变化,组成的变化.这种类型的二氧化物是 diterpenoids.肠道毒性 肠道毒性模拟处理是模拟处理的过程.更多相关视频
03:48Author Spotlight: Exploring the Mysteries of Sichuan's Herbal Medicine in Chinese Medicine Research
Published on: March 1, 2024
1.2K
08:22Author Spotlight: A New and Efficient Method for Comprehensive Metabolite Cytotoxicity Assessment of Triazole Pesticides in Plants
Published on: December 22, 2023
545
相关概念视频
01:14Prevention of Further Absorption of Poison
In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
01:26Anticholinesterase Agents: Poisoning and Treatment
Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is slower than the...
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is slower than the...
01:18Effects of EDTA on End-Point Detection Methods
Different methods, such as visual observance of metal-ion indicators, spectroscopic techniques, and potentiometric methods, can determine the endpoint of an EDTA titration.
In the visual method, metal-ion indicators (metallochromic dyes), which have distinct colors in their free and complex forms, are added to the mixture to signal the titration's end point. They form stable complexes with metal ions, but these complexes are weaker than the corresponding metal–EDTA complexes. As a result, EDTA...
In the visual method, metal-ion indicators (metallochromic dyes), which have distinct colors in their free and complex forms, are added to the mixture to signal the titration's end point. They form stable complexes with metal ions, but these complexes are weaker than the corresponding metal–EDTA complexes. As a result, EDTA...
01:24Drug Toxicity: Dose-Dependent Reactions
Drug toxicities can be stratified into pharmacological, pathological, or genotoxic based on their mechanisms. The incidence and severity of these toxicities generally increase with the drug's concentration in the body and exposure time.Pharmacological toxicity is evident when the therapeutic effects of drugs overshoot into adverse reactions in a predictable, dose-dependent manner. Central nervous system (CNS) depression from barbiturates is a classic example, with effects escalating from...
01:30Drug toxicity: Drug–Drug Interaction
Drug–drug interactions can precipitate toxicity through multiple mechanisms. Absorption interactions alter how drugs enter the body, exemplified when ranitidine increases the absorption of basic drugs, while cholestyramine decreases the levels of propranolol. Protein binding interactions occur when drugs share the same binding sites on plasma proteins. Drugs like aspirin and warfarin, when bound in excess, can lead to increased free drug concentrations, enhancing the potential for...