[对Jingu Zhitong Gel的功能物质进行皮肤间扩散研究]
Lu Li1, Jia-Qing Li1, Wen-Jun Liu1
1National Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture,Jiangsu Kanion Pharmaceutical Co., Ltd. Lianyungang 222001, China.
这项研究优化了Jingu Zhitong Gel (JGZTG) 通过皮肤传递,揭示了活性化合物的16小时的受控释放. 这确保了稳定的血液药物度,与临床剂量计划保持一致.
科学领域:
- 药理动力学和药物输送方法
- 皮肤病学和局部配方
- 自然产品化学 自然产品化学
背景情况:
- 京津凝 (JGZTG) 是一种局部配方,需要优化通过皮肤扩散才能有效.
- 了解JGZTG活性成分的扩散动力学对于治疗应用至关重要.
研究的目的:
- 系统地研究JGZTG功能成分的皮肤传播规律.
- 建立一个优化的方法来评估JGZTG通过皮肤扩散.
- 为了确定关键化合物的释放概况和扩散动力学超过16小时.
主要方法:
- 使用自动化透皮 (干热) 取样系统进行单因子试验.
- 开发了一种高性能液体染色学 (HPLC) 方法,用于定量酸,森基努化物I,酸和桑托西林衍生物.
- 使用老鼠皮肤作为通过皮肤的屏障,以正常的盐水作为接收介质.
主要成果:
- 确定了最佳的JGZTG透皮扩散参数:0.3g剂量,乙烯酸提取.
- 费鲁酸,肉酸和森基努化物I在0-8小时内显著释放,随后按照希古奇和里特格-佩帕斯模型减缓.
- 桑托西林衍生物通过骨溶解呈现连续释放,坚持零级,第一级和Ritger-Peppas方程.
结论:
- JGZTG证明其活性成分的控制释放,确保药物在血液中的度稳定长达16小时.
- 在12小时内累积的传导率达到24小时传导率的80%,支持每天两次的剂量方案 (bis in die).
- 已建立的透皮扩散方法和动力学分析为评估类似局部配方提供了强大的框架.
更多相关视频
11:07Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging
Published on: November 24, 2021
05:27Gap Junctional Intercellular Communication: A Functional Biomarker to Assess Adverse Effects of Toxicants and Toxins, and Health Benefits of Natural Products
Published on: December 25, 2016
相关概念视频
Methods for Studying Drug Absorption: In vitro
The diffusion cell method uses a two-compartment cell, including a donor compartment with the drug solution, which simulates the environment where the drug is applied, and a receptor compartment with a buffer solution, which simulates the environment...
Methods for Studying Drug Absorption: In situ
The Doluisio method involves perfusing a prepared segment of a rat's small intestine with a solution of radiolabeled drug and a non-absorbable marker. This helps to differentiate between absorbed and non-absorbed drug concentrations. The intestinal segment is connected at both ends using tubing and syringes,...
Passive Diffusion: Overview and Kinetics
When administered orally, drugs establish a substantial concentration gradient between the gastrointestinal (GI) lumen and the bloodstream, expediting...
Non-Oral Extravascular Drug Absorption Routes
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
Drug Absorption Mechanism: Passive Membrane Transport
