心肌功能障碍与生物标志物的关系,COVID-19的严重程度和所有原因的死亡率
Jianxiong Chen1,2, Lin Jin3, Mengjiao Zhang4
1Department of Ultrasound, Shanghai General Hospital of Nanjing Medical University, Shanghai, China.
ESC heart failure
|May 30, 2024
概括
COVID-19可能会导致心肌损伤. 这项研究发现,COVID-19患者减少的全球环周应变 (GCS) 与较高的死亡风险有关.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 心声回声扫描 (Echocardiography) 是一种心声回声扫描.
背景情况:
- COVID-19 感染与心肌损伤有关.
- 在COVID-19患者中,左心室菌株参数 (GLS,GCS,GRS),疾病严重程度和死亡率之间的关系需要澄清.
研究的目的:
- 调查左心室全球纵向菌株 (GLS),全球周边菌株 (GCS) 和全球辐射菌株 (GRS) 与COVID-19严重程度和全因死亡率之间的关联.
主要方法:
- 在220名COVID-19患者中利用二维斑点跟踪回声心脏学来分析GLS,GCS和GRS.
- 使用考克斯回归和卡普兰-梅尔曲线评估了菌株参数,心脏生物标志物 (BUN,cTnI) 和全因死亡率之间的关联.
- 随访患者平均为11天,其中19人达到终点 (死亡).
主要成果:
- 在所有三个菌株参数和血尿素 (BUN) 水平之间发现了显著的关联.
- 心脏中托罗邦素I (cTnI) 水平与GLS和GCS相关.
- 一个GCS大于-21.6%显著与所有原因死亡的风险增加相关 (危险比率:4.007).
结论:
- 左心室GLS,GCS和GRS与COVID-19患者的心肌功能障碍显著相关.
- 恶化GCS是COVID-19幸存者的死亡风险增加的一个关键指标.
相关概念视频
Blood Studies for Cardiovascular System I: Cardiac Biomarkers
137
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
137
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
77
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
77
Imbalances in Cardiac Output
1.4K
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
1.4K
Pathophysiology of Cardiac Performance
635
Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
635


