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纤维化和矩阵金属蛋白酶 (MMPs) 的发生

Antonella La Russa¹, Raffaele Serra², Teresa Faga³

¹Nephrology Unit, Department of Health Sciences, Magna Graecia University, 88100 Catanzaro, Italy.

Frontiers in bioscience (Landmark edition)

|May 30, 2024

概括

矩阵金属蛋白酶 (MMPs) 通过促进细胞过渡来驱动纤维化. 本综述详细介绍了MMPs,特别是MMP-9,如何促进慢性病 (CKD) 的进展.

科学领域:

腎臟病學 (nephrology) 是一種醫學專業.
分子生物学分子生物学
生物化学生化学

背景情况:

慢性病 (CKD) 的特点是的结构和功能变化,往往导致纤维化.
纤维化涉及通过矩阵金属蛋白酶 (MMPs) 降解细胞外基质 (ECM) 蛋白质.
组织金属蛋白酶抑制剂 (TIMPs) 是MMP活性的关键调节剂.

研究的目的:

阐明MMPs在CKD中导致纤维化的机制.
专注于MMP-9和上皮-介质酶过渡 (TEM) 在纤维化中的作用.

主要方法:

对MMP,TIMP和纤维化现有文献的综述.
对MMP参与细胞转分化过程的分析.
检查MMP-9对TEM的具体贡献.

主要成果:

MMPs参与了关键的纤维细胞过程,包括管状上皮层-介质细胞过渡 (TEM),内皮层-介质细胞过渡 (EndoMT) 和纤维细胞激活.
MMP-9因其在促进TEM的重要作用而被突出,这是纤维化的一个关键步骤.
对MMP和TIMP的失调有助于在CKD期间ECM重塑的不平衡.

结论:

通过诱导细胞转变,MMPs,特别是MMP-9,是CKD中纤维化的关键调解者.
向MMP可能提供一种治疗策略,以减轻纤维化和CKD进展.
了解MMP-ECM相互作用对于开发治疗病的有效方法至关重要.

关键词:

时间表 (TIMPs)灭症 (apoptosis) 是一种死亡的过程.细胞信号传递是细胞的信号传递.慢性脏疾病慢性脏疾病脏纤维化脏纤维化管状上皮细胞是管状上皮细胞.

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