与强度相关的基因表达对最大强度的急性反应和强度感知敏度的急性反应
Muammer Altun1, Erdal Balcan2, Sevinç Batir2
1Department of Training Education, Faculty of Sport Sciences, Manisa Celal Bayar University, Manisa, Turkiye.
Turkish journal of medical sciences
|May 30, 2024
概括
高肌肉强度会损害力感 (FS). 这项研究发现FS敏度与特定基因表达之间的相关性,表明这种关系的基础是分子机制,特别是ACE和ACTN3基因.
科学领域:
- 运动生理学 运动生理学
- 分子生物学分子生物学
- 生物化学 生物化学
背景情况:
- 高肌肉强度与力量感 (FS) 敏度的下降有关.
- 关联肌肉强度和受损FS的潜在分子机制尚不清楚.
研究的目的:
- 研究降低FS敏度与与力量相关基因的表达之间的关系.
- 探索潜在的分子途径,涉及的恶化力感与增加的肌肉力量的感觉.
主要方法:
- 22名受试者接受了最大自愿同度收缩 (MVIC) 和FS测试.
- 定量实时PCR (qRT-PCR) 用于在运动期间和运动后的不同时间点分析血液样本中的基因表达.
主要成果:
- 在MVIC和FS错误值之间发现了显著的相关性 (r = .659,p = .001).
- IL-6,ACTN3,ACE,BDNF和CNTFR基因的表达在亚最大收缩期间增加,并在运动后减少.
- 随着FS误差的增加,ACE和ACTN3基因表达水平显著上升,这表明与受损的力感知有联系.
结论:
- 运动期间和运动后的基因表达模式对于理解力感至关重要.
- 较高的最大力可能会导致力敏度的恶化,这可能是由观察到的基因表达变化和细胞代谢变化所介导的.
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