口服的八胺囊和帕尔图索丁用于治疗巨症
David S McLaren1,2, Khyatisha Seejore1,2, Julie Lynch1
1Department of Endocrinology, Leeds Centre for Diabetes & Endocrinology, Leeds Teaching Hospital NHS Trust, Leeds, UK.
TouchREVIEWS in endocrinology
|May 30, 2024
概括
新的口服索马托斯塔丁受体连接体 (SRLs) 改善了患者对壮症治疗的满意度. 口服的八丁囊和帕尔图索丁为注射提供了方便的替代品,具有可比的疗效和安全性.
科学领域:
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
- 在瘤学瘤学.
背景情况:
- 可注射的索马托斯塔丁受体连接体 (iSRL) 是标准的积症治疗方法,但由于注射部位反应和不便,其满意度很低.
- 患者经常在注射周期结束时经历症状突破,影响健康.
- 已开发出口服索马托斯塔丁受体连接体 (SRL),以改善患者的接受和坚持.
研究的目的:
- 评估口服索马托他因子受体连接体 (SRLs) 的疗效和安全性,作为巨注射疗法的替代方案.
- 为了比较口服八胺囊 (OOC) 和paltusotine与现有的可注射索马托斯塔丁受体连接体 (iSRL) 的有效性.
主要方法:
- 口服八胺囊 (OOC) 使用肠道涂层和透性增强剂来提高口服生物可用性,达到与皮下注射相当的水平.
- 第三阶段研究评估了OOC在以前接受iSRL的患者中保持生化控制的能力.
- 第二阶段研究评估了paltusotine在壮病患者的疗效,评估从iSRL切换后的胰岛素样生长因子I (IGF-I) 水平.
主要成果:
- 在60%以上的患者中,OOC保持了相当的生化控制,并显示了长达3年的持续反应.
- 在13周后,Paltusotine在87%的患者中保持了IGF-I控制在基线的20%以内.
- 对OOC和paltusotine的不良事件与iSRL的不良事件相似.
结论:
- 口服八胺囊 (OOC) 和paltusotine是对壮症治疗的宝贵补充,提供了更好的便利和患者满意度.
- 需要进一步的研究,以充分确定这些口服药物的长期疗效,瘤控制和缩潜力,以治疗巨.
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