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Updated: Jun 25, 2025

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胃癌期间肠道微生物组的改变:对病例对照研究的证据评估
Ruimin Zhang1,2, Yingxin Wu1,2, Wantao Ju1,2,3
1Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu, China.
Frontiers in microbiology
|May 30, 2024
概括
这一元分析揭示了胃癌患者的显著肠道微生物群变化,特定的细菌属,如乳杆菌和链球菌显示增加了丰富. 这些变化往往是特定于国家和样本来源的.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
背景情况:
- 胃癌是全球重要的健康问题.
- 肠道微生物群失生症越来越多地与包括癌症在内的各种疾病有关.
- 了解这些微生物变化对于潜在的诊断或治疗策略至关重要.
研究的目的:
- 系统地识别和分析与胃癌相关的肠道微生物组成的变化.
- 进行对病例控制研究的元分析,调查胃癌中的肠道微生物组.
- 探索这些微生物变化的国家和样本来源特定变化.
主要方法:
- 在主要数据库 (PubMed,Embase,Cochrane图书馆,Web of Science) 的系统文献搜索.
- 纳入病例控制研究,比较患有胃癌和没有胃癌的个体的微生物组.
- 使用随机效应模型进行元分析,并进行子组和灵敏度分析;使用Stata 17.0.0分析数据.
主要成果:
- 对33项研究 (4,829名参与者) 的分析显示,阿尔法多样性 (香农指数) 的显著变化.
- 十一种细菌属显示出显著的变化,包括乳酸菌和菌株菌株的增加,以及Porphyromonas和Rothia的减少.
- 具体国家分析显示,韩国人的Helicobacter和Streptococcus增加,葡萄牙患者的Neisseria减少;对于Bacteroides,观察到样本来源的差异.
结论:
- 在胃癌患者的9个细菌系中确定了强大的,特定于国家和样本来源的变化.
- 这些发现凸显了肠道微生物群和胃癌之间的复杂相互作用.
- 需要进一步的大规模研究来阐明潜在的机制.
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