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Updated: Aug 1, 2026

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
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通过整合生物信息学分析和分子对接模拟来识别杏仁母细胞瘤和药物重新定位的分子机制

Suthipong Chujan1,2, Nutsira Vajeethaveesin3, Jutamaad Satayavivad1,2

  • 1Laboratory of Pharmacology, Chulabhorn Research Institute, Bangkok, Thailand.

Bioinformatics and biology insights
|May 30, 2024
PubMed
概括

这项研究确定了乳腺母细胞瘤 (AM) 中的关键分子通路,并发现FOS蛋白作为潜在的治疗点. 坦斯皮米辛对FOS表现出显著的结合 afinity,为AM提供了一个有前途的新治疗策略.

关键词:
生物信息学分析艾梅洛母细胞瘤 (Ameloblastoma) 是一种药物重新定位 药物重新定位分子对接模拟分子对接模拟坦斯皮米辛的使用情况

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Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...