在抗脂综合征中进行血栓形成风险评估:非标准抗体是否有助于?
Ömer Uludağ1, Suzan Çinar2, Thomas McDonnell3
1Division of Rheumatology, Department of Internal Medicine, İstanbul Faculty of Medicine, İstanbul University, İstanbul, Turkiye.
Turkish journal of medical sciences
|May 30, 2024
概括
全球抗脂综合征评分 (GAPSS) 和调整的GAPSS (aGAPSS) 有效预测抗脂抗体阳性 (aPL+) 患者的血管血栓 (VT) 风险. 其他非标准的aPL抗体并没有改善超出GAPSS得分的血栓形成预测.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 血管医学 血管医学
背景情况:
- 抗脂综合征 (APS) 与血管血栓形成 (VT) 的风险增加有关.
- 预测分数系统对于APS和相关条件中的风险分层至关重要.
- 非标准抗脂抗体 (aPL) 在血栓形成预测中的作用需要进一步澄清.
研究的目的:
- 为了评估非标准aPL的预测值,除了血管血症 (VT) 的全球抗脂综合征评分 (GAPSS) 之外.
- 评估GAPSS和调整的GAPSS (aGAPSS) 在预测APS和aPL阳性全身性红斑狼 (SLE) 患者的静脉瘤的疗效.
主要方法:
- 对50名初级APS,68名SLE/APS和52名aPL阳性SLE患者进行了横截面研究.
- 抗脂血清学包括狼抗凝剂,抗心素 (IgG/IgM/IgA),抗β2糖蛋白I (IgG/IgM/IgA),抗脂/原素 (IgG/IgM) 和抗域I (IgG).
- 计算了GAPSS和aGAPSS;进行了逻辑回归分析,结果是血栓形成.
主要成果:
- 与aPL阳性SLE患者相比,在静脉瘤患者中,GAPSS和aGAPSS都显着更高.
- 在患有复发性血栓塞的患者中,调整后的GAPSS (aGAPSS) 值较高.
- 一个GAPSS≥13和aGAPSS≥10显示出血栓形成的最佳预测值;后勤回归证实了一个GAPSS≥13作为唯一的显著预测因素.
结论:
- 在aPL阳性患者中,GAPSS和aGAPSS有效预测血栓形成风险.
- 非标准的aPL抗体,特别是aCL IgA,aβ2GPI IgA和aDI IgG,没有提高GAPSS或aGAPSS对血栓形成的预测能力.
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