在地中海人口中,疼痛管理变异的药物遗传景观
Haifa Jmel1,2,3, Wided Boukhalfa1,2,3,4, Ismail Gouiza1,2,3,4,5
1Laboratory of Biomedical Genomics and Oncogenetics, Institut Pasteur de Tunis, Tunis, Tunisia.
Frontiers in pharmacology
|May 30, 2024
概括
地中海群体对疼痛管理具有独特的药物遗传特征,与全球群体不同. 这些发现突出了该地区个性化缓解疼痛的潜在生物标志物.
科学领域:
- 药物遗传学 药物遗传学
- 基因组学就是基因组学.
- 计算生物学 计算生物学
背景情况:
- 慢性疼痛在地中海地区是一个重大的社会经济挑战.
- 现有的关于疼痛管理的药物遗传学研究不足以代表地中海人群.
- 了解疼痛途径的遗传变异对于个性化医学至关重要.
研究的目的:
- 与全球人口相比,分析地中海人口的药物遗传景观.
- 为了确定个性化疼痛管理的潜在治疗生物标志物.
- 通过使用in silico方法调查参与疼痛管理的药物基因途径.
主要方法:
- 使用PRISMA指南和PharmGK数据库收集了与疼痛相关的基因和变异.
- 分析了829个个体的基因型数据,使用多变量和混合分析 (R,结构).
- 确定了miRNA结合点,并进行了途径丰富,注释和对接分析.
主要成果:
- 确定了63种疼痛管理基因变异;地中海人群与墨西哥人群的遗传相似性以及与其他群体的分歧.
- 在人群中突出了三个COMT基因变异 (rs633,rs4680,rs165728) 的等位基因频率差异.
- 发现了具有潜在miRNA结合位点的10个变体和影响COMT蛋白活性的2个误解变体 (rs4680,rs6267).
结论:
- 地中海人群具有与疼痛管理相关的独特遗传特征.
- 与疼痛相关的途径和微RNA对于开发地中海地区止痛反应预测剂很重要.
- 这项研究支持为地中海人群开发个性化疼痛管理策略.
相关概念视频
Analgesia and Pain Management
579
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
579
Opioid Receptors: Overview
729
Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2,...
729
Opioid Analgesics: Synthetic and Semisynthetic Opioids
276
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
276
Opioid Analgesics: Morphine and Other Natural Cogeners
234
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
234
Human Genetics
559
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
559
Genome-wide Association Studies-GWAS
13.3K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.3K


