用酒精清洁静脉穿刺部位是否会影响血液中乙醇度?
Deniz Kılıç1, Adeviyye Aksoy1, Ramazan Sivil1
1Department of Emergency Medicine, University of Heath Sciences, Antalya Training and Research Hospital, Antalya, Turkey.
Heliyon
|May 30, 2024
概括
用乙醇杀菌静脉穿刺部位不会显著影响血液中乙醇度 (BEC) 的测量. 这一发现对于准确的急诊室诊断和法律评估至关重要,特别是对于低BEC水平的患者.
科学领域:
- 临床化学 临床化学
- 毒理学 毒理学 毒理学
- 紧急医疗 紧急医疗
背景情况:
- 精确的血液乙醇度 (BEC) 测定在急诊室 (ED) 对于患者的诊断,治疗和法律目的至关重要.
- 在ED中,使用以乙醇为基础的消毒剂用于静脉穿刺部位灭菌的做法是常见的.
- 乙醇灭菌对BEC测量的潜在影响需要调查.
研究的目的:
- 为了评估静脉穿刺部位的乙醇灭菌是否会影响BEC测量.
- 为了确定BEC读数的可靠性,当在血液抽取之前使用以乙醇为基础的消毒剂.
主要方法:
- 一项涉及94名需要BEC测量的患者入院ED的比较研究.
- 从每个参与者身上采集了两份血液样本,采用了不同的静脉穿刺技术:一种是10%的波维- (参考),另一种是89%的乙醇消毒剂.
- 两种消毒剂都被允许在飞骨切除术前空气干燥30秒,并使用酒精脱酶酶酶法测量BEC.
主要成果:
- 在基准 (2 mg/dL) 和乙醇灭菌 (2 mg/dL) 技术 (p=0.536) 之间的BEC水平中位数没有观察到统计学上显著的差异.
- 对BEC<20 mg/dL的患者的布兰德-阿尔特曼分析显示,最小的平均偏差为-0.116 mg/dL.
- 协议的界限很窄,这表明这两种方法在低BEC水平之间具有良好的一致性.
结论:
- 在静脉穿刺之前以乙醇为基础的皮肤灭菌不会导致在度低于20 mg/dL的患者中错误地提高BEC水平.
- 这些发现支持在ED环境中继续使用基于乙醇的消毒剂,用于BEC样本采集.
- 即使使用乙醇灭菌,也可以实现准确的BEC确定.
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