在患有原发性甲状腺功能低下症的患者中影响适当levothyroxine治疗的查因素:一个横截面研究
Zainab Hussein Ali1, Manal Khalid Abdulridha2, Qusay Baqer Alzajaji3
1Department of Clinical Pharmacy, College of Pharmacy, Kerbala University, Kerbala, Iraq.
Journal of medicine and life
|May 30, 2024
概括
患者的知识,态度和实践 (KAP) 显著影响一次性甲状腺功能低下症治疗结果. 治疗抑郁症以及药物坚持对于在甲状腺功能低下患者中有效的勒沃西 (LT4) 管理至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 内部医学 内部医学
- 公共卫生 公共卫生
背景情况:
- 初级甲状腺功能低下症是最常见的甲状腺功能低下症.
- 有效的患者理解和管理对于成功的长期治疗至关重要.
- 患者的知识,态度,实践 (KAP),抑郁和药物坚持等因素可以影响治疗反应.
研究的目的:
- 研究患者KAP,抑郁症和药物坚持对初级甲状腺功能低下症治疗反应的影响.
- 评估患者特征与治疗结果之间的关系.
- 识别导致治疗反应不足最佳的因素.
主要方法:
- 进行了一项横截面的观察性研究,对111名甲状腺功能低下的主要患者进行了观察.
- 经过验证的调查问卷评估了患者的KAP,抑郁症和药物坚持.
- 测量甲状腺刺激激素 (TSH) 水平以评估治疗反应.
主要成果:
- 34%的患者没有足够的知识,30%的患者有积极的态度;35%的患者表现出良好的实践.
- 高等教育与改善的KAP分数相关;与年龄或性别无关.
- 44.1%的人报告有中度抑郁症,58%的人坚持服用勒沃西 (LT4). 公平的知识和中度至重度的抑郁导致了尽管坚持良好,但结果不够理想.
结论:
- 患者KAP,抑郁症和药物坚持是初级甲状腺功能低下症管理的重要因素.
- 低于最佳的治疗结果甚至可以发生在良好的坚持,如果知识是公平的,抑郁症是存在的.
- 针对患者教育和心理健康的干预措施对于改善初级甲状腺功能低下症治疗反应至关重要.
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