在荷兰,肺癌查和同时提供戒烟支持的预计有效性
Koen de Nijs1, Kevin Ten Haaf1, Carlijn van der Aalst1
1Department of Public Health, Erasmus MC - University Medical Center Rotterdam, 3015 CE Rotterdam, The Netherlands.
EClinicalMedicine
|May 30, 2024
概括
低剂量CT肺癌查可在符合条件的人群中降低16.9%的死亡率. 将查与戒烟支持相结合,进一步增长了寿命,使其成为一个关键的公共卫生战略.
科学领域:
- 在瘤学瘤学.
- 公共卫生 公共卫生
- 医疗成像医学成像
背景情况:
- 尼尔森试验显示,通过低剂量计算机断层扫描 (LDCT) 查,肺癌死亡率降低了24%.
- 欧洲实施肺癌查需要调整的益处和危害估计.
研究的目的:
- 估计荷兰群体每两年一次的肺癌查与戒烟支持的有效性.
- 为实施欧洲肺癌查提供国家具体数据.
主要方法:
- 使用了MISCAN-Lung微显模拟模型,对NELSON试验数据进行校准.
- 模拟吸烟行为,肺癌发病率和死亡率结果在100%的查合规性下.
- 包括同时进行的戒烟干预措施.
主要成果:
- 在符合条件的人群中,两年一次的查减少了肺癌死亡率16.9% (21.5%的队列).
- 在过去的20年里,每年预防了大约1076例肺癌死亡.
- 每个肺癌死亡被预防的寿命增加了10.3年,每个寿命增加了14.9次.
- 戒烟干预措施使终身年增长率高达20%.
结论:
- 肺癌查,特别是与戒烟相结合时,可显著降低死亡率并增加寿命.
- 政策制定者应该优先考虑在欧洲实施肺癌查计划.
- 戒烟干预措施本身并不能提供与查一样大的预期寿命增长.
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